Procedure for Calibration of Balances in pharmaceutical industry

 MONTHLY CALIBRATION OF BALANCES 

For monthly Calibration of Balances check following parameters-

1. Accuracy - verify the balance with minimum weight (least count × 100), 5%, 20%, 50%, 90% capacity of respective balance capacity.

Tolerance - the variation if any should be ± least count of the balance or ± 0.2% of certified standard weight used whichever is higher 

 2. Reproducibility - 

Check the reproducibility by using minimum standard weight of balance capacity. Place the weight in the middle of the weighing pan observe the displayed value 

Then calculate the %RSD by following formula 

RSD= SD×100 / X 

Where, 

X= mean of the individual value

Acceptance = %RSD should not be more than 2.0%

3. Eccentricity 

Eccentricity is the difference between the weight placed in centre and at peripheral points of the weighing pan 

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Types of granulation in tablet formulation

TYPES OF GRANULATION
Granulation can be achieved by three method as follows :-
1. Direct compression   
      Crystalline substance like sodium chloride, sodium bromide may be compressed directly. The vast majority of medicinal agents are rarely so easy to tablet, direct compression material should posses good flow and compresibility and must be inert, tasteless, able to disintegrate and inexpensive.
Method
(Drug + filler + disintegrant + lubricant + glidant ) all are blend directly after sifting through Viber sifter and compressed


2. Dry Granulation
   It is used in situations where effective dose of a drug is too high for direct compaction and the drug is sensitive to heat, moisture, or both which preclude wet granulation. This is also called slugging method.
Method
A.      (Drug + filler + lubricant) All are.       blend then precompression done and     after that   comminution done
 
 B.  (glidant + lubricant + disintigrant)  sizing then blend with A

3. Wet Granulation
  Wet granulation forms the granules by binding the powders together with an adhesive, instead of by compaction. Liquid bridge are developed between particles, and the tensile strength of these bond increase as the amount of liquid binder added is increased. A drying process is required in all wet granulation to remove the solvent and to reduce the moisture content. After drying granulation is screened again, followed by compression.

Schematic drawing of All types granulation

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WALK IN FOR ACME GENERICS LLP ON 5th AUG 2017

We are looking for Executive/Officers/Operators Position in QA/QC/Production/HR department for our manufacturing facility at North India

Find below detailed advertisement below

Who we are:

A Leading Pharma Group with Global Presence and approvals from EU-GMP, MHRA-UK, ANVISA Brazil, PICS Ukraine, WHO Geneva, INVIMA Colombia, USFDA*

We have 3 facilities in North India and 1 R&D centre at Bengaluru ,

1. Immacule Lifesciences- Manufacturing of Liquid and Lyophillized injections approved from MHRA, ANVISA, PICS Ukraine, USFDA Scheduled

2. Acme Formulation Pvt Ltd- Comprises of 2 blocks (General & Hormone) , manufacturing Tablets, Capsules approved by WHO Geneva

3. Acme Generics LLP - Comprises of 2 blocks (General & Thyroxine) , manufacturing Tablets, Capsules approved by EU-GMP

This position is for

Company Name: Acme Generics

Location: Baddi (Himachal Pradesh) near Chandigarh

Multiple Positions:

Production (Manufacturing) and Packing Operations-Experience in Coating/Granulation/ Compression/ Capsule/Alu- Alu/Blister/ Strip/ areas.

Quality Assurance- Experience in IPQA/QMS/Validation/ Qualification with thorough knowledge of cGMP norms.

Quality Control- Experience in Instrumental and chemical analysis i.e. RM/PM/FG/Validation/Micro/ Stability on instruments like HPLC, GC, UV, IR.

Human Resources- Experience in Recruitment/ Talent Acquisition /Payroll/ Liasoning / Statutory Compliances/Admin Activities.

Designation: Executives/Officers/Operators

Experience: 1- 8 years of experience in Pharmaceutical Industry

Educational Qualification: B. Pharma / M. Pharma / B. Sc / M. Sc / MBA H.R

Salary: Negotiable(Best in Industry)

Interview Venue:

Acme Generics LLP

Plot No. 115, HPSIDC Industrial Area, Davni, Manpura near Baddi (H.P)

Date & Time:

05th August 2017 (Saturday) ,

9:00 am onwards

Ph: 01795-332612-60

Contact: HR Team

hr@acmegenerics.in

Note: Candidates who are able to relocate to Baddi (H.P) and join us immediately can only apply

Interested and eligible candidates are advised to appear for WALK-IN along with updated CV, passport size Photograph and salary supportings.

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BEST INTERVIEW TIPS FOR A GOOD JOB IN PHARMACEUTICAL COMPANY

BEST INTERVIEW TIPS FOR A GOOD JOB IN PHARMACEUTICAL COMPANY