LIST OF CRITICAL PARAMETERS DURING GRANULATION
During
the process of granulation in tablet manufacturing a number of parameters to be
considered here some of them listed
1.
Cleaning of area prior to granulation
2.
Maintain environmental conditions
3.
Absence of foreign particles
4.
Types of binder
5.
Types of binding (impeller & chopper speed and
timing)
6.
Temperature of drying
7.
Time of drying
8.
Loss on drying
9.
Final granule size
10. %
compressibility
11. Flow
of powder
12. Ratio
of granules
13. Lubricants
used
14. Timing
of mixing and lubrication
15. Storage
conditions of RFC powder.